| Impact | Widespread destruction, radical climate change, radioactive zones |
| Setting | Post-nuclear war world |
| Factions | The Brotherhood of Steel • New California Republic • Caesar's Legion |
| Timeline | 1964-present |
| New threats | Mutated creatures • proliferation of radioactive zones • territorial disputes |
| Global event | Nuclear war |
| Rebuilding efforts | In progress • Fallout settlements • Vault cities |
| Decreased population | Yes |
| Surviving civilizations | Scattered small settlements near extreme latitudes |
